GLUZIN™ Benefits

You understand the importance of zinc is vital for your health, and non-compliance is an ongoing problem for many of us.

Generally, three factors cause non-compliance:

• Product cost versus quality
• Hard-to-swallow tablets
• Allergenic ingredients

GLUZIN™ is made from Pharmaceutical Grade USP standard raw materials and is manufactured in facilities that meet or exceed all current Good Manufacturing Practice (GMP) requirements. Gluzin™ has been formulated with minimum fillers to help reduce allergic reactions.

GLUZIN™ is an essential trace mineral zinc supplement you can recommend with confidence, and trust in its purity. It’s available at a price you can afford.

At extreme™ V, we’ve recognized and answered your needs:  Purity you can trust

• No fear of allergens or wasteful fillers.
• Two dosage forms: 50 mg, (capsule size 1) and 25 mg (capsule size 3) for patients with special needs.
• Our unique production process allows us to charge less money than some other manufacturers.
• Rigorous production batch validations, stability and dissolution testing, and product analysis regimens are based on pharmaceutical-level Standard Operating Procedures (SOPs) and conducted in third-party Good Laboratory Practice (GLP) facilities to assure the highest, purest quality.
• Available over the counter as a dietary supplement. Gluzin™ delivers high value at an affordable cost.
• Available worldwide.

GLUZIN™ ZINC GLUCONATE

Gluzin™ supports the replenishment of normal healthy zinc levels and balances the interactions of your essential trace elements. Gluzin™ is formulated with Pharmaceutical Grade Zinc Gluconate. Zinc is a naturally occurring mineral and is essential for immune system health.

Uses
Zinc is important for the growth and development of healthy body functions. Zinc Gluconate supports the replenishment of normal healthy zinc levels.

Description
Gluzin™ comes in two dosage forms:
25 mg (Capsule size 3) and 50 mg (Capsule size 1)

INCI Designation
Zinc Gluconate

CAS No.
4468-02-4

Physical and Chemical Properties
Empirical Formula: C12H22O14Zn
Molecular Weight: 455.685 g/mol
Chemical Structure:

Specifications
Appearance: White granules
Odor: Odorless
Heavy Metals (as Pb): Not more than 0.001%
Arsenic (AS2O3): Not more than 0.0003%
Assay (dry basis): 97.0% – 102%

Solubility
Soluble in water.

Stability
Stable in temperature and humidity.

Recommended Daily Dose
As a dietary supplement, take one capsule daily.

Other Ingredients
Gelatin (capsules), Magnesium Stearate.

Allergenic Ingredients
No sugar, no starch, no artificial flavors, no preservatives, sodium free, no wheat, no gluten, no corn, no soy, no dairy, yeast free, no lactose.

Physiological Function

• Supports the replenishment of normal healthy zinc levels.
• Zinc blocks the intestinal absorption of copper from the diet.
• Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately
• 100 enzymes and it plays a role in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.

Absorption and Tissue Deposition
Most exogenous zinc is absorbed transcellularly in the small intestine, where the jejunum exhibits the greatest transport rate. Absorption kinetics are saturable, and efficiency of intestinal zinc absorption increases with transit time and zinc deficiency. Over 85 percent of total body zinc is incorporated into skeletal muscle and bone. Plasma zinc, bound primarily to albumin at a concentration of approximately 10-15 umol/L, represents only 0.1% of total body levels.

Formulating Techniques
Good dissolution profile, contains minimal excipients, contains no excipients that will cause allergic reactions.

Side Effects
Zinc is considered to be relatively nontoxic, particularly if taken orally. However, manifestations of overt toxicity symptoms (nausea, vomiting, epigastric pain, lethargy, and fatigue) will occur with extremely high zinc intakes. Even lower levels of zinc supplementation, closer in amount to the Recommended Dietary Allowance (RDA) (100-300 mg Zn/d vs. an RDA of 15 mg Zn/d), have been suggested to interfere with the utilization of copper and iron and to adversely affect HDL cholesterol concentrations. Individuals using zinc supplements should be aware of the possible complications attendant to their use. Do not exceed recommended dose.

Storage
Keep out of reach of children. Store in a cool, dry place.

Packaging
High Density Polyethylene (HDPE) with tamper resistance cap-ring.

GLUZIN™ Manufacturing Facility

• Gluzin™ is manufactured under Good Manufacturing Practice (GMP).
• Production batch validations, stability and dissolution testing, and product analysis regimens are based on pharmaceutical-level Standard Operating Procedures (SOPs) to assure the highest, purest quality.
• Final Formulated products are validated in third-party Good Laboratory Practice (GLP) facilities.
• Manufacturing facility has been audited by 3rd party auditor and various global Regulatory organizations.

GLUZIN™ Certificate of Analysis

GLUZIN™ Dissolution Profile

• Dissolution profile: In vitro dissolution test showed that Gluzin™ dissolved 100% within 10 minutes of testing time.
  • 25 mg (RSD% = 4.9, mean value 100.7)
  • 50 mg (RSD% = 3.18, mean value 102.2)